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KMID : 0043319870100030149
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Archives of Pharmacal Research
1987 Volume.10 No. 3 p.149 ~ p.152
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Protective Effect of Diallyl Disulfide on Ethacrynic Acid-Induced Toxicity in Mice
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Huh K
Lee SI/Song JW
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Abstract
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The present work was undertaken to investigate the effect of diallyl disulfide on ethacrynic acid toxicity. Ethacrynic acid-induced mortality and formation of lipid peroxide were inhibited by diallyl disulfide. Furthermore, decreasing effect of glutathione S-transferase and glutathione level in the liver by ethacrynic acid were reduced by diallyl disulfide. These results suggested that the inducing effect of diallyl disulfide on the ethacrynic acid metabolizing enzyme, glutathione S-transferase, is believed to be a possible detoxication mechanism for the ethacrynic acid toxicity in mice.
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